Meeting Banner
Abstract #2070

The Origins of FMRI Contrast in SPEN Imaging at Ultra High Magnetic Fields

Eddy Solomon1, Nadya Pyatigorskaya2, Peter Bendel1, Denis Le Bihan2, Luisa Ciobanu2, Lucio Frydman1

1Weizmann Institute of Science, Rehovot, Israel; 2Neurospin, CEA, Saclay, France

This presentation examines the origin of the function-derived activation detected by SPEN fMRI, with a series of preclinical high (7T) and ultra-high (17.2T) magnetic field studies. Artifact-free images of a rats head with good resolution in all areas and localized activation maps were obtained in a single scan using a variety of SPEN sequences. Our data shows that, besides the normal T2*-weighted BOLD contribution which arises in non-refocused sequences, fMRI SPEN signals contains a strong component caused by apparent T1-related inflow effects. This contribution can be modulated by varying the scanning repetition rate; measurements at 7T support this finding.