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Abstract #2119

Finding Thalamic BOLD Correlates to Cortical Alpha Modulation

Zhongming Liu1, Jacco A. de Zwart1, Bing Yao1, Peter van Gelderen1, Li-Wei Kuo1, Jeff H. Duyn1

1Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States

Simultaneous EEG-fMRI data were analyzed to reveal the thalamocortical networks associated with the modulation of cortical alpha (8-12Hz) EEG. The occipital alpha rhythm was found to be negatively correlated with the BOLD signals at both the visual cortex and the visual thalamus but positively at the anterior dorsal nuclei, which was neither structurally nor functionally connected with the visual cortex. Negative thalamic BOLD-alpha correlation was mostly found at Pulvinar, as confirmed by comparison with reference locations defined through functional localizer with visual stimulation as well as high-resolution anatomical images with gradient echo phase contrast at 7T.