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Abstract #2145

fMRI Neurofeedback of Kinesthetic Motor Imagery

Mark Chiew1, 2, Stephen M. LaConte3, 4, Simon J. Graham1, 5

1Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Rotman Research Institute, Toronto, Ontario, Canada; 3Virginia Tech Carilion Research Institute, Virginia Tech, Roanoke, VA, United States; 4Virginia Tech Wake Forest University School of Biomedical Engineering and Sciences,, Virginia Tech, Blacksburg, VA, United States; 5Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada

Functional MRI neurofeedback (fMRI NF) enables subjects to regulate their brain activity by viewing and manipulating their fMRI signals in real-time. Here we present an fMRI NF study of brain activity in the left and right primary motor (M1) ROIs associated with kinesthetic motor imagery, analyzed offline using partial least squares methods. Using a differential feedback measure (left M1 - right M1 and vice versa), we found subjects were more successful at suppressing activity in the ipsilateral M1 than up-regulating activity in the contralateral M1, and that task success was correlated with expression of task-positive network regions.