Jianli Wang1, Xiaoyu Sun1, Zackary Herse1, Megha Patel1, Sarah Ryan1, Jeffrey Vesek1, Qing X. Yang1, 2
1Radiology, Penn State College of Medicine, Hershey, PA, United States; 2Neurosurgery, Penn State College of Medicine, Hershey, PA, United States
As the brains BOLD signal responding to odorant stimulation is strongly modulated by habituation and respiration, quantitative assessment of olfactory deficits in the brain using fMRI is complex. A thorough understanding of the dynamic behavior of the BOLD signal due to habituation in the central olfactory system is essential for clinical applications of olfactory fMRI. Published fMRI studies on human olfactory habituation have been limited. In this study, we characterized the dynamic behavior of the BOLD signal in human primary olfactory cortex and related structures when subjected to odor habituation.
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