Basil Knnecke1, Andreas Bruns1, Eric Prinssen1, Jean-Luc Moreau1, Joseph G. Wettstein1, Markus von Kienlin1, Cline Risterucci1
1CNS Research, F. Hoffmann-La Roche Ltd, Basel, Switzerland
Preclinical pharmacological fMRI (phMRI) has been successfully used to elucidate the effects of psychoactive drugs on regional cerebral activity, but comparative meta-analyses of study ensembles are largely missing. The present work provides such a systematic and quantitative analysis of perfusion-based phMRI data obtained upon interventions with an extensive set of neuroactive reference compounds impacting on the domains of anxiety and depression. Neural activity patterns detected by phMRI were subjected to principal component analysis in order to yield specific signatures for the drugs modes-of-action and objective measures of dose-effect and treatment duration-effect relationships.