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Abstract #2184

High Temporal Resolution In-Vivo Blood Oximetry Via Projection Based T2 Measurement

Varsha Jain1, Jeremy Magland1, Michael Langham1, Felix W. Wehrli1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Measuring oxygen saturation (SvO2) in large blood vessels can provide important information about oxygen delivery and its consumption. Quantification of bloods T2 value can be utilized to determine SvO2.We propose a fast method for blood T2 quantification via computing the complex difference of velocity-encoded projections.Average resting state SvO2 measurements in superior sagittal sinus,straight sinus, left and right internal jugular veins in the three subjects were 653 %, 701%, 683% and 693%, respectively, in agreement with previous reports. Additionally, in concurrence with the known vasoldilatory effect of hypercapnia SvO2 levels increased by ~10%HbO2. Potential clinical applications extend to the study of pathological conditions affecting cerebral metabolism, for example, neurodegenerative conditions such as Alzheimers dementia.