High Temporal Resolution In-Vivo Blood Oximetry Via Projection Based T2 Measurement

Varsha Jain¹, Jeremy Magland¹, Michael Langham¹, Felix W. Wehrli¹

Measuring oxygen saturation (SvO2) in large blood vessels can provide important information about oxygen delivery and its consumption. Quantification of bloods T2 value can be utilized to determine SvO2.We propose a fast method for blood T2 quantification via computing the complex difference of velocity-encoded projections.Average resting state SvO2 measurements in superior sagittal sinus,straight sinus, left and right internal jugular veins in the three subjects were 653 %, 701%, 683% and 693%, respectively, in agreement with previous reports. Additionally, in concurrence with the known vasoldilatory effect of hypercapnia SvO2 levels increased by ~10%HbO2. Potential clinical applications extend to the study of pathological conditions affecting cerebral metabolism, for example, neurodegenerative conditions such as Alzheimers dementia.