Characterization of CEST Effect from Glucose In Vitro

Sai Chilakapati¹, Sanjana Reddy¹, Mohammad Haris¹, Anup Singh¹, Kejia Cai¹, Kavindra Nath², Hari Hariharan¹, Ravinder Reddy¹

In the current study, we characterized the chemical exchange saturation transfer effect (CEST) effect from glucose at brain physiological concentration (<10mM) using different saturation pulse power and saturation duration and image them at high spatial resolution in In Vitro on 7T human scanner. The CEST peak was observed at ~1 ppm and showed linear relation with glucose concentration. The next step is to monitor the change in the brain glucose concentration after intravenous injection of glucose using the optimized saturation parameters.