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Abstract #2335

Characterization of CEST Effect from Glucose In Vitro

Sai Chilakapati1, Sanjana Reddy1, Mohammad Haris1, Anup Singh1, Kejia Cai1, Kavindra Nath2, Hari Hariharan1, Ravinder Reddy1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Molecular Imaging Lab, University of Pennsylvania, Philadelphia, PA, United States

In the current study, we characterized the chemical exchange saturation transfer effect (CEST) effect from glucose at brain physiological concentration (<10mM) using different saturation pulse power and saturation duration and image them at high spatial resolution in In Vitro on 7T human scanner. The CEST peak was observed at ~1 ppm and showed linear relation with glucose concentration. The next step is to monitor the change in the brain glucose concentration after intravenous injection of glucose using the optimized saturation parameters.