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Abstract #2336

Pharmacological MRI by Dynamic CEST Imaging

Sheng-Min Huang1, Yun-Hsuan Lin1, Yi-Chun Wu2, Yi-Jui Liu3, Fu-Nien Wang1

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 2Molecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 3Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan

CEST MRI has been showed for the ability of detecting the change of chemical microenvironment, such as pH level. In this study, dynamic amide proton transfer CEST imaging was first utilized for pharmacological MRI on a normal rat model. The Z-spectra were dynamically scanned after administration of methamphetamine. Different responses were discovered between cortex and striatum during methamphetamine challenge. Dynamic CEST imaging was demonstrated for the feasibility of observation of the drug effect and providing additional information.