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Abstract #2377

Experimental Demonstration of Diffusion Signal Enhancement in 2D DESIRE Images

Ileana Ozana Jelescu1, Nicolas Boulant1, Denis Le Bihan1, Luisa Ciobanu1

1NeuroSpin, CEA/DSV/I2BM, Gif sur Yvette, France

As opposed to standard diffusion-weighted sequences, the DESIRE (Diffusion Enhancement of SIgnal and REsolution) method gains signal through diffusion. We implemented 2D DESIRE with 60 μm spatial resolution and evaluated enhancement in three media: water (D≈1.5x10-3 mm2/s), thin and thick silicone oils (D≈1.8x10-4 mm2/s and D≈9x10-6 mm2/s, respectively), following a saturation time of 336 ms. Average enhancement in the DESIRE images was 3 in water, 1.9 in thin oil and zero in thick oil, confirming that the stronger the diffusion, the greater the enhancement. The application of the technique to imaging barriers and multi-compartment phantoms is in progress.