Abstract #2378

Mapping of Oxygen by Imaging Lipids Relaxation Enhancement (MOBILE): Application to Monitor Peripheral Ischemia in a Mouse Model.

Julie Magat¹, Patrice D. Cani², Nathalie Delzenne², Bernard Gallez¹, Bndicte F. Jordan¹

¹Biomedical Magnetic Resonance Group, Universit Catholique de Louvain, Brussels, Belgium; ²Metabolism and nutrition Group, Universit Catholique de Louvain, Brussels, Belgium

Techniques able to assess quantitative peripheral pO2 are mandatory to verify the efficacy of therapeutic approaches aimed to salvage limbs in diabetic patients with critical limb ischemia. We recently developed a method able to map variations in oxygenation based on the changes in the relaxation properties of the tissue lipids by exploiting the higher solubility property of oxygen in lipids than in water. The aim of the current work was to apply the MOBILE technique in order to map peripheral tissue oxygenation in a mouse model of peripheral ischemia.