Uncertainty of Quantitative T1 Mapping in Healthy Volunteers at 7.0 Tesla

Daniel Polders¹, Alexander Leemans², Peter Luijten¹, Hans Hoogduin³

This study utilizes a slice shifted EPI based T₁ mapping technique to calculate T₁maps over the human brain, sampling the inversion curve at 23 inversion times in 4 minutes 10 seconds. Then, wild bootstrapping was applied to determine the uncertainty of the fitted T₁values. This approach allows for simultaneous mapping of both T₁ and the uncertainty in T₁. Knowledge of regional T1 and its uncertainty is essential for interpretation if differences between regions of interest or subjects.