Daniel Polders1, Alexander Leemans2, Peter Luijten1, Hans Hoogduin3
1Radiology, UMC Utrecht, Utrecht, Netherlands; 2Image Sciences Institute, UMC Utrecht, Utrecht, Netherlands; 3Rudolf Magnus Institute of Neuroscience, Department of Neurology and Neurosurgery, UMC Utrecht, Utrecht, Netherlands
This study utilizes a slice shifted EPI based T1 mapping technique to calculate T1maps over the human brain, sampling the inversion curve at 23 inversion times in 4 minutes 10 seconds. Then, wild bootstrapping was applied to determine the uncertainty of the fitted T1values. This approach allows for simultaneous mapping of both T1 and the uncertainty in T1. Knowledge of regional T1 and its uncertainty is essential for interpretation if differences between regions of interest or subjects.