Sankaran Subramanian1, Nallathamby Devasahayam1, Shingo Matsumoto1, Cherukuri M. Krishna1
1National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
Time-domain Electron Spin Resonance Imaging at RF frequency (300 MHz) has been developed for mapping oxygen distribution in mouse models of tumor. Oximetry is based on the relaxivity of in vivo pO2 on trityl radicals infused intravenously into the animals. A combination of spin echo and single point (constant-time) imaging (SPI) leads to highly resolved images with T2-weighting and generates quantitaive sptailly resolved oxygen ditribution maps.