Abstract #2540

Improving SNR and Sensitivity of 3D Fluorine Imaging with a Side-Information-Constrained Regularized Reconstruction

Samuel Fielden¹, Alexander Klibanov¹,², Yaquin Xu¹, Frederick Epstein¹,³, Brent French¹,³, Craig Meyer¹,³

¹Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; ²Medicine, University of Virginia; ³Radiology, University of Virginia

Second color, or hot spot, fluorine imaging benefits from 3D acquisition from both a signal localization point of view and a desire to maximize signal sensitivity. Here we show fluorine nanoparticle-labeled macrophage infiltration into infarcted myocardium using a gated 3D turbo spin echo sequence, and improve the SNR and sensitivity using a regularized reconstruction technique which utilizes side information obtained from proton scout images.