Meeting Banner
Abstract #2540

Improving SNR and Sensitivity of 3D Fluorine Imaging with a Side-Information-Constrained Regularized Reconstruction

Samuel Fielden1, Alexander Klibanov1, 2, Yaquin Xu1, Frederick Epstein1, 3, Brent French1, 3, Craig Meyer1, 3

1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; 2Medicine, University of Virginia; 3Radiology, University of Virginia

Second color, or hot spot, fluorine imaging benefits from 3D acquisition from both a signal localization point of view and a desire to maximize signal sensitivity. Here we show fluorine nanoparticle-labeled macrophage infiltration into infarcted myocardium using a gated 3D turbo spin echo sequence, and improve the SNR and sensitivity using a regularized reconstruction technique which utilizes side information obtained from proton scout images.