Yajing Zhang1, Jiangyang Zhang2, Michael I. Miller, 13, Susumu Mori2
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States; 2Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 3Center of Imaging Science, Johns Hopkins University, Baltimore, MD, United States
An MR based brain atlas is a key component in modern image analysis process. In this study, a population-based brain atlas with preserved image resolution was generated from normal aged control and age-matched AD datasets, using a continuous fluid dynamic model. This so-called VTE atlas presents a group averaged shape that minimize its anatomical bias while preserves sharp contrast for accurate image mapping. The characteristics of the new atlas were examined with respect to single subject atlases and group averaged atlases. The registration accuracy by using the new atlas was compared with commonly used single subject atlas through kappa analysis.