Abstract #2571

Investigation of the Resolution Dependence of White Matter Structure Analysis by Means of Variography

Fabian Keil¹, Daniel Brenner¹, Ana-Maria Oros-Peusquens¹, N. Jon Shah¹,²

¹Institute of Neuroscience and Medicine - 4, Forschungszentrum Jlich, Jlich, Germany; ²JARA - Faculty of Medicine, RWTH Aachen University, Aachen, Germany

Variography is a novel method for the quantification of heterogeneities and spatial correlations in 3D MP-RAGE images of white matter. This abstract investigates the resolution dependence of variographic analyses applied to MR images. The change of the variogram is demonstrated and analysed by means of a digitised, high-resolution photograph of a human brain slice. A method for the correction of resolution-based changes is introduced and applied to the low resolution variograms. The estimated correlation parameters of corrected, uncorrected and native variograms are compared and evaluated.