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Abstract #2571

Investigation of the Resolution Dependence of White Matter Structure Analysis by Means of Variography

Fabian Keil1, Daniel Brenner1, Ana-Maria Oros-Peusquens1, N. Jon Shah1, 2

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Jlich, Jlich, Germany; 2JARA - Faculty of Medicine, RWTH Aachen University, Aachen, Germany

Variography is a novel method for the quantification of heterogeneities and spatial correlations in 3D MP-RAGE images of white matter. This abstract investigates the resolution dependence of variographic analyses applied to MR images. The change of the variogram is demonstrated and analysed by means of a digitised, high-resolution photograph of a human brain slice. A method for the correction of resolution-based changes is introduced and applied to the low resolution variograms. The estimated correlation parameters of corrected, uncorrected and native variograms are compared and evaluated.