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Abstract #2836

An Assessment of the Post-Stimulus Undershoot Using Hyperoxic BOLD Contrast and ASL

Ian D. Driver1, Emma L. Hall1, Paula L. Croal1, Susan T. Francis1, Penny A. Gowland1

1Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, United Kingdom

The BOLD post-stimulus undershoot (PSU) following a motor task is assessed at 7T through simultaneous measurement of BOLD, CBF, and venous CBV using hyperoxia. This work shows a post-stimulus undershoot in both the BOLD and CBF response, when the venous CBV response had returned to baseline. This suggests a neuronal origin for the PSU, but could also result from a delayed vascular compliance. Results show that at the spatial resolution (2 x 2 x 3 mm3), the PSU is not more localised to the underlying neuronal response, as reported in animal models.