Meeting Banner
Abstract #2837

Dynamic Compartment-Specific Cerebral Blood Volume and BOLD Responses to Electrical Forepaw Stimulation in α-Chloralose Anesthetized Rats

Xiaopeng Zong1, Tae Kim1, Seong-Gi Kim1

1Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States

Studying the compartment-specific dynamic cerebral blood volume responses is important for quantitative fMRI studies and understanding the dynamic properties of BOLD fMRI responses. In this study, we measured BOLD, arterial (ΔCBVa), venous (ΔCBVv), and total cerebral blood volume responses to electrical forepaw stimulation in α-chloralose anesthetized rats using a magnetization transfer-varied fMRI technique and injection of paramagnetic contrast agent. We found a fast ΔCBVa response and a delayed slower ΔCBVv response. Our findings are consistent with earlier studies under different anesthesia conditions and support the anesthesia independence of the fast CBVa and slow CBVv dynamic properties.