Dynamic Compartment-Specific Cerebral Blood Volume and BOLD Responses to Electrical Forepaw Stimulation in α-Chloralose Anesthetized Rats

Xiaopeng Zong¹, Tae Kim¹, Seong-Gi Kim¹

Studying the compartment-specific dynamic cerebral blood volume responses is important for quantitative fMRI studies and understanding the dynamic properties of BOLD fMRI responses. In this study, we measured BOLD, arterial (ΔCBV_a), venous (ΔCBV_v), and total cerebral blood volume responses to electrical forepaw stimulation in α-chloralose anesthetized rats using a magnetization transfer-varied fMRI technique and injection of paramagnetic contrast agent. We found a fast ΔCBV_a response and a delayed slower ΔCBV_v response. Our findings are consistent with earlier studies under different anesthesia conditions and support the anesthesia independence of the fast CBV_a and slow CBV_v dynamic properties.