Increased Temporal Resolution in FMRI Using Hadamard-Encoding with Phase Correction and Physiological Noise Removal

Alan Chu¹, Jon-Fredrik Nielsen¹, Douglas C. Noll¹

Hadamard-encoded fMRI is a multi-slice acquisition method that potentially increases temporal resolution compared to conventional, single-slice fMRI. Because Hadamard-encoded fMRI is relatively more susceptible to signal variations from both physiological and non-physiological sources, it is critical to perform appropriate noise removal for the method to perform well. In this abstract, we outline the proper processing needed for Hadamard-encoded fMRI, and show that the results have increased temporal resolution without a decrease in activation quality.