Meeting Banner
Abstract #2911

Dependence of Cerebral Blood Flow and Oxygen Consumption on Hyperoxia-Induced Changes in the Longitudinal Relaxation Time

David Thomas Pilkinton1, Ravinder Reddy1

1Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

This work aims to develop a biophysical model that relates blood flow and oxygen consumption to the observed T1 decrease in tissues during hyperoxia. Showing opposite trends compared to hyperoxic effects on R2 (BOLD), hyperoxic R1 enhancement increases as CBF increases and metabolism decreases. Using hypercapnia to induce an isometabolic increase in CBF, our model captures effects on R1 due to this physiological parameter during hyperoxia. Since a comprehensive validation of this model requires measuring hyperoxia as a function of metabolism, future work will focus on altered metabolic states.