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Abstract #2912

Hyperoxic Calibrated Quantitative FMRI for the Measurement of Regional Cerebral Metabolic Rate of Oxygen in a Hypermetabolic Swine Model

David T. Pilkinton1, Victor K. Babu1, Wesley Baker1, Joel H. Greenberg2, Ravinder Reddy1

1Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

The aim of this study is to quantify relative metabolic changes using hyperoxic calibrated BOLD/ASL fMRI in a hypermetabolic swine model. Metabolic changes using this large animal model were previously studied by our group using gas that is isotopically-enriched with 17O2. We sought to cross-validate these measurements with hyperoxic dHb dilution methods of relative metabolism and to compare the results of hyperoxia and hypercapnia calibration methods using this animal model.