Abstract #2912

Hyperoxic Calibrated Quantitative FMRI for the Measurement of Regional Cerebral Metabolic Rate of Oxygen in a Hypermetabolic Swine Model

David T. Pilkinton¹, Victor K. Babu¹, Wesley Baker¹, Joel H. Greenberg², Ravinder Reddy¹

¹Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; ²Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

The aim of this study is to quantify relative metabolic changes using hyperoxic calibrated BOLD/ASL fMRI in a hypermetabolic swine model. Metabolic changes using this large animal model were previously studied by our group using gas that is isotopically-enriched with 17O2. We sought to cross-validate these measurements with hyperoxic dHb dilution methods of relative metabolism and to compare the results of hyperoxia and hypercapnia calibration methods using this animal model.