Abstract #2915

Acute and Chronic Effects of Glucose on Brain Metabolism: Findings from Healthy Subjects and Diseased Conditions

Feng Xu¹, Peiying Liu¹, Juan Pascual², Xuchen Zhang², Hanzhang Lu¹

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; ²Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States

The glucose is the primary source of energy for the brain and its effect on brain metabolism is not well understood. With a recently developed technique quantifying cerebral metabolic rate of oxygen (CMRO2), we studied the acute and chronic effect of glucose on healthy controls and GLUT-1 deficiency (GLUT-1 DS) patients who suffer the chronic hypoglycemia in the brain. In healthy subjects, the acute increase of glucose reduced CMRO2. The baseline CMRO2 of Glut-1DS patients is lower than healthy controls, and was elevated after the glucose ingestion.