Christopher MacLellan1, 2, David Fuentes1, Andrew Elliott1, Jon Schwartz3, John Hazle1, 2, R. Jason Stafford1, 2
1Imaging Physics, UT MD Anderson Cancer Center, Houston, TX, United States; 2The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, United States; 3Nanospectra Biosciences, Houston, TX, United States
Nanoparticles must be well characterized and implemented into bioheat transfer models for full utilization in MR-guided laser interstitial thermal therapy (MRgLITT). We report on an inverse problem approach that recovers optical properties using the results of bioheat transfer simulations and MR temperature imaging. Optimized properties were found to be within 5% of the literature values for gold nanoshells and nanorods using this method. This provides a minimally invasive approach that can determine optical properties of nanoparticle mixtures without independent simulations of particle properties.