Yuxi Pang1, 2, Baris Turkbey2, Marcelino Bernardo2, 3, Jochen Kruecker4, Samuel Kadoury4, Maria J. Merino5, Bradford Wood6, Peter A. Pinto7, Peter
1Philips Healthcare, Cleveland, OH, United States; 2Molecular Imaging Program, National Cancer Institute, Bethesda, MD, United States; 3SAIC-Frederick, Bethesda, MD, United States; 4Philips Research North America, Briarcliff Manor, NY, United States; 5Laboratory of Pathology, National Cancer Institute, Bethesda, MD, United States; 6Diagnostic Radiology Department-Clinical Center, National Institutes of Health, Bethesda, MD, United States; 7Urologic Oncology Branch, National Cancer Institute, Bethesda, MD, United States
This work is to evaluate the performance of intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) MRI for prostate cancer detection. Thirty three patients underwent diffusion weighted (DW) imaging with five b-values, T2W and DCE-MRI. Diffusion coefficients (D) and perfusion fraction (f) were derived from an asymptotic curve-fitting based on the IVIM model. The results showed that D differentiated tumors from normal tissues in the prostate using all possible combinations of non-zero b-values; however, f demonstrated large variations depending on the choice of b-values. Exclusion of the highest b-value of 750 (s/mm2) led to better correlations of f with DCE-MRI.