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Abstract #2968

Intravoxel Incoherent Motion Perfusion Measurement Correlated with DCE-MR Imaging in Prostate Cancer Detection

Yuxi Pang1, 2, Baris Turkbey2, Marcelino Bernardo2, 3, Jochen Kruecker4, Samuel Kadoury4, Maria J. Merino5, Bradford Wood6, Peter A. Pinto7, Peter

1Philips Healthcare, Cleveland, OH, United States; 2Molecular Imaging Program, National Cancer Institute, Bethesda, MD, United States; 3SAIC-Frederick, Bethesda, MD, United States; 4Philips Research North America, Briarcliff Manor, NY, United States; 5Laboratory of Pathology, National Cancer Institute, Bethesda, MD, United States; 6Diagnostic Radiology Department-Clinical Center, National Institutes of Health, Bethesda, MD, United States; 7Urologic Oncology Branch, National Cancer Institute, Bethesda, MD, United States

This work is to evaluate the performance of intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) MRI for prostate cancer detection. Thirty three patients underwent diffusion weighted (DW) imaging with five b-values, T2W and DCE-MRI. Diffusion coefficients (D) and perfusion fraction (f) were derived from an asymptotic curve-fitting based on the IVIM model. The results showed that D differentiated tumors from normal tissues in the prostate using all possible combinations of non-zero b-values; however, f demonstrated large variations depending on the choice of b-values. Exclusion of the highest b-value of 750 (s/mm2) led to better correlations of f with DCE-MRI.