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Abstract #2977

Clinically Feasible Quantitative Breast DCE-MRI Protocol with High Spatial and Temporal Resolutions

Karen Y. Oh1, Luminita A. Tudorica1, Nicole Roy1, Mark D. Kettler1, Xin Li1, Yiyi Chen1, Aneela Afzal1, John W. Grinstead2, Gerhard Laub3, Wei Huang1

1Oregon Health & Science University, Portland, OR, United States; 2Siemens Healthcare, Portland, OR, United States; 3Siemens Healthcare, San Francisco, CA, United States

Thirty one patients with 36 suspicious breast lesions underwent DCE-MRI prior to biopsies using a commercially available GRE-based TWIST sequence, a k-space undersampling and data sharing acquisition strategy. 18 or 20 s temporal resolution was obtained along with 1x1x1.4 mm3 spatial resolution. Single-frame DCE images were acquired immediately following TWIST DCE-MRI using a conventional full-k-space-sampling GRE sequence. Excellent intra- and inter-radiologist reader agreement in tumor morphology evaluation was achieved when comparing the last TWIST DCE image set with the conventional GRE images. Shutter-Speed model pharmacokinetic analyses of TWIST DCE-MRI data improved diagnostic accuracy compared to that obtained with ACR BIRADS Lexicon.