Yuan Le1, Christian Geppert2, Randall Kroeker2, Brian Dale2, Chen Lin1
1Radiology, Indiana University, Indianapolis, IN, United States; 2Siemens Healthcare, Erlangen, Germany
Computer simulations have been performed to study the error caused by TWIST view sharing on the measured breast dynamic contrast enhancement. A digital breast phantom was generated with spherical lesions of different sizes and three types of enhancement curves: persistent, plateau and wash-out. The results suggest that for lesion larger than 5mm, TWIST view sharing with greater 33% central k-space region and more than 50% peripheral sampling density would preserve the curve type information. Such imaging parameters are suitable for clinical breast DCE MRI.