Simulations of the Impact of TWIST View Sharing on the Measured Enhancement in Breast DCE MRI

Yuan Le¹, Christian Geppert², Randall Kroeker², Brian Dale², Chen Lin¹

Computer simulations have been performed to study the error caused by TWIST view sharing on the measured breast dynamic contrast enhancement. A digital breast phantom was generated with spherical lesions of different sizes and three types of enhancement curves: persistent, plateau and wash-out. The results suggest that for lesion larger than 5mm, TWIST view sharing with greater 33% central k-space region and more than 50% peripheral sampling density would preserve the curve type information. Such imaging parameters are suitable for clinical breast DCE MRI.