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Abstract #3004

Clinical Evaluation of Breast DCE MRI with TWIST DIXON Sequence

Yuan Le1, Randall Kroeker2, Hal D. Kipfer3, Shadie S. Majidi3, Stephanie Holz3, Brian Dale2, Chen Lin1

1Radiology, Indiana University, Indianapolis, IN, United States; 2Siemens Health Care, Erlangen, Germany; 3Radiology and Imaging Science, Indiana University, Indanapolis, IN, United States

A novel pulse sequence (TWIST DIXON)which combines k-space data sharing strategy used in Time-resolved angiography With Stochastic Trajectories (TWIST) with fat and water separation by dual-echo DIXON was evaluated for breast DCE MRI application. In this study, we compared the image quality of TWIST DIXON sequence with the conventional method of fat suppressed 3D spoiled gradient echo sequence in a group of clinical patients. The results demonstrate that TWIST DIXON technique provides significantly higher perceived SNR, more accurate fat suppression and overall better image quality.