Abstract #3003

Correlation of Molecular Biomarker (ER, PR, HER2/neu Status) with Total Choline Concentration and Tumor Volume in Breast Cancer Patients: Using an MRI and in vivo Proton MRS

Naranamangalam Raghunathan Jagannathan¹, Rani G. Sah¹, Uma Sharma¹, Vurthaluru Seenu², Sandeep Mathur³, Rajinder Parshad²

¹Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; ²Department of Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India; ³Department of Pathology, All India Institute of Medical Sciences, New Delhi, Delhi, India

The total choline (tCho) concentration and tumor volume were determined using in-vivo MRS and MRI in 73 invasive ductal carcinoma patients at 1.5T with known HER2/neu, ER and PR status. The tCho concentration in HER2+ (3.81.2), ER+ (5.02.7) and PR+ (5.02.8) patients was not significantly different as compared to HER2- (4.4 2.9), ER-(4.32.8) and PR- (4.72.9) patients. Tumor volume in ER+ patients was significantly lower compared to patients with ER-. The increase in the volume may be attributed to higher microvessels density in ER- patients. Also no significant difference in tCho concentration and tumor volume was observed with PR status.