Abstract #3002

Association of Total Choline Concentration and Tumor Volume in Triple Negative (TN), Non-Triple Negative (NTN) and Triple Positive (TP) Breast Cancer Patients: An MRI and in vivo Proton MRS Study

Rani G. Sah¹, Uma Sharma¹, Rajinder Parshad², Vurthaluru Seenu², Sandeep Mathur³, Naranamangalam Raghunathan Jagannathan¹

¹Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; ²Department of Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India; ³Department of Pathology, All India Institute of Medical Sciences, New Delhi, Delhi, India

tCho concentration and tumor volume were determined using in-vivo MRS and MRI in triple negative (TN), non-triple negative (nTN) and triple positive (TP) breast cancer patients. TN patients were of younger age (28 to 39 yrs) compared to nTN and TP patients. tCho concentration was significantly lower in TN (3.8 1.0 mmol/kg) compared to nTN (4.7 3.1 mmol/kg) and TP (5.4 2.5 mmol/kg) patients while tumor volume was similar in all patients. Reduced choline kinase expression and high degradation of phosphatidylcholine might have led to lower tCho in TN patients; however, this warrants further investigations.