Abstract #3021

Non-Invasive Quantification of Anti-Angiogenic Therapy by Contrast Enhanced MRI in Experimental Pancreatic Cancer

Hans-Juergen Raatschen¹, Christian Olaf Schoenfeld¹, Birgit Hotz², Hubert G. Hotz²

¹Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany; ²General, Vascular and Thoracic Surgery, Charit Universittsmedizin Berlin, Berlin, Germany

Pharmacokinetic analysis of dynamic, albumin-(Gd-DTPA)-enhanced MRI appears to be a sensitive method to quantify angiogenesis-inhibiting effects of bevacizumab and suramin well before changes in tumor volumes can be detected and thus might be a useful addition to morphological MRI in the follow-up of antiangiogenic cancer treatment.