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Abstract #3021

Non-Invasive Quantification of Anti-Angiogenic Therapy by Contrast Enhanced MRI in Experimental Pancreatic Cancer

Hans-Juergen Raatschen1, Christian Olaf Schoenfeld1, Birgit Hotz2, Hubert G. Hotz2

1Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany; 2General, Vascular and Thoracic Surgery, Charit Universittsmedizin Berlin, Berlin, Germany

Pharmacokinetic analysis of dynamic, albumin-(Gd-DTPA)-enhanced MRI appears to be a sensitive method to quantify angiogenesis-inhibiting effects of bevacizumab and suramin well before changes in tumor volumes can be detected and thus might be a useful addition to morphological MRI in the follow-up of antiangiogenic cancer treatment.