Rat Liver Tumor Treated with a Vascular Disrupting Agent Combined with an Antiangiogenic: Enhanced Antitumor Efficacy Evaluated by MRI

Feng Chen¹, Kaier Zheng², Frederik De Keyzer¹, Raymond Oyen¹, Yicheng Ni¹

Our randomized, controlled study demonstrated that the combination of a vascular disrupting agent with an antiangiogenic (ZdTha) enhanced overall antitumor efficacy due to synergistic effects. ZdTha induced cumulative tumor necrosis, and thus, significantly decreased tumor volume and reduced the viable tumor rim; ZdTha also reduced tumor vessel permeability and improved tumor hemodynamic indexes via a transient normalization of tumor vasculature induced by Tha. Finally, the ADC value at 12 d was shown to be an independent predictor of changes in tumor volume. These therapeutic effects were successfully tracked and evaluated with in vivo multiparametric MRI.