Abstract #3023

Probing Tumor Early Response to Radiation Therapy Using Hyperpolarized [1-13C]pyruvate in a Breast Cancer Model

Albert P. Chen¹, Yi-Ping Gu², Michelle Ladouceur-Wodzak², William Chu³, Charles H. Cunningham²,⁴

¹GE Healthcare, Toronto, ON, Canada; ²Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; ³Radiation Oncology, University of Toronto, Toronto, ON, Canada; ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada

Changes in the [1-¹³C]lactate signal observed in vivo following injection hyperpolarized [1-¹³C]pyruvate have been shown to be a marker for early treatment response. With the emergence of hypofractionated radiation therapy, this tool for detecting early response to treatments non-invasively may be very important for management of certain cancers. In this study, early and significant change in hyperpolarized [1-¹³C]lactate signal in tumors was observed after a single, large dose of radiation therapy in a human breast cancer model.