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Abstract #3063

3D Tracking of Transient Peri-Infarct Depolarizations in Ischemic Rat Brain by Fast ADC Mapping

Victor E. Yushmanov1, Alexander Kharlamov1, Stephen R. Yutzy2, Prahlad G. Menon1, 3, Paul A. Schornack2, Erik C. Wiener2, Fernando E. Boada2, Stephen C. Jones, 2

1Department of Anesthesiology, Allegheny-Singer Research Institute, Pittsburgh, PA, United States; 2Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States; 3Department of Bioengineering, Carnegie-Mellon University, Pittsburgh, PA, United States; 4Departments of Anesthesiology and Neurology, Allegheny-Singer Research Institute, Pittsburgh, PA, United States

Peri-infarct depolarizations (PIDs) in the brain are a major pathogenic factor in experimental ischemic stroke. The protocols for 3D PID tracking suitable for use in combination with brain K+ imaging were developed and refined. Transient changes in difference ADC images were tracked by plotting either their center of mass or their front edge in 3D. PID tracks were followed, segment by segment, throughout the whole brain beyond the usual position of a cranial window in traditional PID observation techniques, and the speed and direction of each individual PID segment were analyzed. Full and detailed PID tracking was not previously available.