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Abstract #3064

Recovery of Locomotor Function After Experimental Stroke Correlated with Enhanced Neuronal Integrity After Amphetamine Treatment

Hua-Shan Liu1, Hui Shen1, Hanbing Lu1, Yun Wang1, Yihong Yang1

1National Institute on Drug Abuse, Baltimore, MD, United States

In the present study, we investigated whether the increase of fractional anisotropy in perilesional areas after amphetamine treatment would predict behavioral improvement in an elevated body swing test that has been reliably used to assess neurological behaviors in rats with ischemia stroke. We demonstrated a correspondence between the temporal changes of fractional anisotropy in perilesional areas and locomotor function in stroke rats treated with amphetamine, suggesting that the structural integrity may be used as an imaging biomarker to predict locomotor function recovery.