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Abstract #3083

Preliminary Evidence of DKI Abnormalities in the Hippocampus of a Mouse Model of Down Syndrome

Victor V. Dyakin1, Maria F. Falangola2, 3, David Guilfoyle3, Scott Gerum3, Caixia Hu3, Edward S. Hui2, Ralph Nixon1

1Dementia Research, Nathan Kline Institute, Orangeburg, NY, United States; 2Radiology, Medical University of South Carolina (MUSC), Charleston, SC, United States; 3Medical Physics, Nathan Kline Institute, Orangeburg, New York, NY, United States

Mouse models of Down syndrome have been used to study the morphological abnormalities and the mechanisms underlying DS-associated cognitive disabilities, but very little has been published using in vivo neuroimaging, and there are no MRI diffusion studies in any of these models. In this study, we characterized the Diffusional Kurtosis Imaging patterns associated with the morphological changes in the hippocampus of the 2Cje (Ts2) mice model, showing statistical significant decrease of axial kurtosis and fractional anisotropy, perhaps related to changes in dendritic morphology seen in this model.