Abstract #3084

Correlation of Motor Coordination with in vivo Metabolite Ratios in Lysophosphatidyl Choline Induced Demyelination Model of Multiple Sclerosis: A Sequential In-Vivo Proton MRS Study

Krithika Balasubramanian¹, Uma Sharma¹, Senthil S. Kumaran¹, Anjali Chauhan², Yogendra K. Gupta², Naranamangalam R. Jagannathan¹

¹Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; ²Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, Delhi, India

Correlation between motor coordination changes and in-vivo metabolite ratios was studied at different stages of de- and re-myelination in an experimental model of multiple sclerosis. Demyelination was induced using lysophosphatidyl choline in the internal capsule (ic) area of rat brain. Significant correlation was observed between motor coordination and metabolite ratio which was attributed to the damage to the myelin around the motor fibers during demyelination leading to decreased N-acetyl aspartate (NAA) and increased choline (Cho). The motor coordination subsequently improved during remyelination resulting in increased NAA and decreased Cho.