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Abstract #3115

Can T1-Differentiation in a Magnetization Prepared Turbo Field Echo Sequence at 7T Predict "Persistent Black Hole White Matter Lesions in Multiple Sclerosis?

Katharine Teal Bluestein1, David Pitt2, Aaron Boster2, Andrew Kalnin1, Michael Knopp1, Petra Schmalbrock1

1Radiology, The Ohio State University, Columbus, OH, United States; 2Neurology, The Ohio State University, Columbus, OH, United States

A new T1-weighted IR-TFE sequence is described which can differentiate Multiple Sclerosis white matter lesions into two sub-groups: lesions with short T1 (2200 ms) and those with long T1 (4300 ms). The sequence is compared to 7T white matter attenuation (WHAT), 7T T1w-MPRAGE, and standard clinical 3T FLAIR. The long T1 white matter lesions are assumed to reflect severe tissue damage, potentially identifying persistent T1 "black holes" without the need for follow-up scans.