Katharine Teal Bluestein1, David Pitt2, Aaron Boster2, Andrew Kalnin1, Michael Knopp1, Petra Schmalbrock1
1Radiology, The Ohio State University, Columbus, OH, United States; 2Neurology, The Ohio State University, Columbus, OH, United States
A new T1-weighted IR-TFE sequence is described which can differentiate Multiple Sclerosis white matter lesions into two sub-groups: lesions with short T1 (2200 ms) and those with long T1 (4300 ms). The sequence is compared to 7T white matter attenuation (WHAT), 7T T1w-MPRAGE, and standard clinical 3T FLAIR. The long T1 white matter lesions are assumed to reflect severe tissue damage, potentially identifying persistent T1 "black holes" without the need for follow-up scans.