Abstract #3142

Long Term Effects of Developmental Exposure to LP211, a New Serotonin 7 Receptor (5-HT7) Agonist

Rossella Canese¹, Paola Porcari¹, Luisa Altabella¹, Francesca Zoratto¹, Francesco de Pasquale², Giovanni Laviola¹, Walter Adriani¹

¹Cell Biology and Neurosciences, Istituto Superiore di Sanita', Rome, Italy; ²Institute for Advanced Biomedical Technologies, G. DAnnunzio University, Chieti, Italy

LP211 is an agonist of serotonin (5-hydroxytryptamine, 5-HT) receptor 7 (5-HT7). It is proposed for a role in neurogenesis and in patho-physiological processes like anxiety / depression, cognitive / sleep disturbances, and impaired coping with stress. Here, we investigated the long-term consequences of developmental exposure to LP211 on brain metabolism (by in vivo 1H MRS), anatomy (by DTI) and functionality (by functional connectivity). We detect enduring metabolic, anatomic and functional modifications which may perhaps indicate rearrangement in forebrain networks.