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Abstract #3148

Comparison of Volumes of Cerebellar Lobules on Structural MRI Using Manual and Automatic Segmentation in Normal and Alcohol-Exposed Children

Priya Lakshmi Narayanan1, 2, Christopher Warton1, Sandra W. Jacobson3, 4, Joseph L. Jacobson3, 4, Christopher D. Molteno4, Ernesta M. Meintjes1, 2

1Human Biology, University of Cape Town, Cape Town, South Africa; 2MRC/UCT Medical Imaging Research Unit, Cape Town, South Africa; 3Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine; 4Department of Psychiatry, University of Cape Town

Fetal alcohol syndrome (FAS) is caused by chronic maternal alcohol consumption during pregnancy. It is a significant worldwide health problem and a particularly critical public health issue in South Africa. The highest prevalence of FAS was reported in the wine-growing regions of South Africa. A total of 23 right-handed children aged 11.81.2 years old were scanned for structural analysis of the cerebellum. Cerebellar lobules were manually traced and volumes were estimated manually and compared with automated IBASPM methods. Both the methods showed the difference in volume between control and FAS but the significant difference was not observed in automated method.