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Abstract #3149

7T MRS of Brain GABA Pre and Post Gabapentin Administration in Health Males

Kejia Cai1, Ravi Prakash Reddy Nanga1, Lisa Lamprou2, Claudia Schinstine2, Jacqueline Meeks, Mark Elliott1, Hari Hariharan1, Ravinder Reddy1, Neill Epperson2

1CMROI, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Departments of Psychiatry & Obstetrics/Gynecology, University of Pennsylvania, Philadelphia, PA, United States

Gamma-Aminobutyric acid (GABA) is the major neurotransmitter for fast inhibitory synaptic transmission. Gabapentin which is recently introduced as an antiepileptic drug has been shown to modulate the GABA concentration in vivo in the brain. In this study, using MEGA PRESS based GABA editing sequence at 7T, we demonstrated the feasibility of measuring elevated GABA levels in response to gabapentin administration in healthy volunteers.