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Abstract #3150

Characterizing White Matter Abnormalities in Boys with Autism Spectrum Disorders Using Diffusion Tensor Imaging

Sung-Yeon Park1, Se-Hong Oh, 12, Young-Shin Kim3, Young-Bo Kim1, Keun-Ah Cheon4, Zang-Hee Cho1

1Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, Korea, Republic of; 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3Child Study Center, Yale University School of Medicine, New Haven, CT, United States; 44Department of Child and Adolescent Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of

Autism has been hypothesized to reflect neuronal disconnection. Several recent reports implicate the white matter connectivity in the pathophysiology of autism. Accordingly, we aimed to focus on evaluating the integrity of the brain white matters in Korean boys with high-functioning autism spectrum disorders (ASD) using Diffusion Tensor Imaging (DTI). And our preliminary findings support evidence implicating disturbances in the brain white matter connections in autism particularly in left hemisphere. These findings will help on understanding of more advanced neurobiological basis underlying the social deficits in ASD.