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Abstract #3182

Preoperative Differentiation Between Grade II and III Gliomas Subtypes and Genotypes Using MR Spectroscopy, Perfusion and Diffusion Imaging

Slim Fellah1, Delphine Caudal2, Philippe Dory-Lautrec2, Patrick Viout1, Olivier Chinot3, Philippe Metellus4, Dominique Figarella-Branger5, Virginie Callot1, Patrick J.

1CRMBM, CNRS, Aix-Marseille Univ, Marseille, France; 2Department of Neuroradiology, APHM, Hopital de la Timone, Marseille, France; 3Department of Neurooncology, APHM, Hopital de la Timone, Marseille, France; 4Department of Neurosurgery, APHM, Hopital de la Timone, Marseille, France; 5Department of Phathology and Neuropathology, APHM, Hopital de la Timone, Marseille, France

Preoperative diagnosis of gliomas is challenging and clinically important for therapy planning. Conventional MRI provides valuable information for the preoperative diagnosis of brain tumors but still insufficient in some cases. Moreover, patients with 1p/19q codeletion and/or IDH1 mutation have longer survival than those possessing the wild type. We used a multimodal MRI protocol including diffusion, perfusion and spectroscopy to investigate noninvasively patients with WHO grade II and III oligodendrogliomas and oligoastrocytomas. Our findings helped differentiating these tumors according to their subtypes but also according to their molecular status. This could be helpful for designing customized therapies and for patient management.