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Abstract #3185

Quantification of Hyperoxia Induced Changes in Normal Tissue and Intracranial Glioma Using SWAN Imaging

Bhaswati Roy1, Rishi Awasthi1, Prativa Sahoo2, Sanjay Verma3, Sanjay Behari4, Bal Kishan Ojha5, Ram KS Rathore2, Rakesh Kumar Gupta1

1Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India; 2Mathematics & Statistics, Indian Institute of Technology, Kanpur, India; 3Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore; 4Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, India; 5chhatrapati shahuji maharaj medical university, India

Fifteen (11male and 4female; mean age=43yrs) patients with definitive diagnosis of glioma were imaged on 3T scanner, using SWAN imaging while breathing normal air and after 5 minutes of breathing 100% oxygen. Quantified values of R2*, phase and magnitude showed significant changes on different tumor tissue type in hyperoxia as compare to normoxia. Significant changes was observed in ΔR2*, Δ phase and Δ mag of different tissue type from normal. We conclude that there is differential response to different tumor tissue type to hyperoxia and this information may be of value for tissue classification in brain tumor tissue type in future.