Jamie Near1, Sarah Larkin2, Alexandr Khrapichev3, Peter Jezzard1, Olaf Ansorge2
1FMRIB Centre, University of Oxford, Oxford, Oxfordshire, United Kingdom; 2Department of Neuropathology, University of Oxford; 3Gray Institute for Radiation Oncology and Biology, University of Oxford
Mutations in isocitrate dehydrogenase 1 and 2 define a glioma subtype with improved prognosis. IDH mutated tumours also contain elevated levels of 2HG. Magnetic resonance spectroscopy detection of 2HG may, therefore, provide an important prognostic biomarker in the initial staging of human gliomas. In this study, 12 human glioma tissue specimens were examined ex-vivo using edited magnetic resonance spectroscopy at 9.4 Tesla. 2HG was unambiguously detected in 9 of 11 IDH mutated tumour specimens, suggesting that MRS of 2HG holds potential as an indicator of tumour mutation status.
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