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Abstract #3187

Magnetic Resonance Spectroscopy Identifies Endothelial Growth Factor Receptor Amplification in High-Grade Gliomas.

Bas Idema1, Sandra Sprenger2, Judith Jeuken2, 3, Andre Grotenhuis1, Pieter Wesseling2, Arend Heerschap4

1Neurosurgery, UMC St Radboud, Nijmegen, Gelderland, Netherlands; 2Pathology, UMC St Radboud, Nijmegen, Gelderland, Netherlands; 3PAMM, Eindhoven, Netherlands; 4Radiology, UMC St Radboud, Netherlands

Endothelial Growth Factor Receptor amplification in high-grade glioma is associated with unfavorable prognosis. The aim of our study was to improve non-invasive identification of EGFR amplification in gliomas by MRS. We collected 76 biopsies from 35 patients with a high grade glioma. A preoperative proton 3D multivoxel MRS scan, semi-LASER sequence with an echo time of 30ms, was performed at 3 Tesla. The EGFR status was determined by MLPA in 31 patients. The concentration of glutamine was significantly correlated with EGFR copy number (sensitivity and specificity 100%) and EGFR variant III (sensitivity 100%, specificity 87%).