Quantitation of Diffusion Indices in CMS Rat Model of Depression a DTI Approach.

Hemanth Kumar B.S. ¹, Richa Trivedi¹, Sushanta Kumar Mishra¹, Sadhana Singh¹, Rajendra P. Tripathi¹, Subash Khushu¹

Chronic Mild Stress (CMS) seems to be a valuable model of depression, based on its resemblance with several human depressive symptoms. CMS model was developed and validated using behavioural studies. DTI data was acquired and FA and MD values were calculated by drawing ROIs on respective regions to look for any changes in the MD and FA values during the onset of depression. The microstructural changes observed in different brain regions were documented. To conclude the changes in FA and the MD values obtained reveals that there might be some structral abnormalities taking place in microlevel during the onset of depression.