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Abstract #3211

Quantitative Diffusion Weighted Magnetic Resonance Spectroscopy of Glioma and Metastatic Tumor in Human Brain in vivo

Dandan Zheng1, Zhenghua Liu2, Jing Fang1, Xiaoying Wang2, Jue Zhang1

1Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 2Dept. of Radiology, Peking University First Hospital, Beijing, China

Previous studies showed that DW-MRS offers excellent tools to specifically measure the intracellular response to tumor. The purpose of this study is using DW-MRS to investigate the pathological related changes in apparent diffusion coefficient (ADC) values of metabolites in glioma and metastatic tumor in vivo. The results demonstrate that the ADC values of the cerebral metabolites significantly increase in the metastatic tumor compared to the age matched healthy controls. Also, increase of Cho and Cr was detected in the glioma compared to the opposite unaffected region.