Abstract #3210

Analysis of ADC Change During Cardiac Cycle in Idiopathic Normal Pressure Hydrocephalus: Change in Tap Test

Akihiro Asano¹, Toshiaki Miyati¹, Naoki Ohno², Kan Hirohito³, Mitsuhito Mase⁴, Tomoshi Osawa⁵, Harumasa Kasai³, Nobuyuki Arai³, Masaki Hara³, Yuuta Shibamot

¹Department of Health Science, Graduate School of Medical Science, kanazawa university, Kanazawa, Japan; ²Department of Radiological Technology, kanazawa university Hospital, Kanazawa, Japan; ³Department of Radiology, Nagoya City University Hospital, Nagoya, Japan; ⁴Department of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciencces, Nagoya City University, Nagoya; ⁵Department of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciencces, Nagoya City University, Nagoya, Japan

We have reported that the apparent diffusion coefficient (ADC) obtained from diffusion MRI in the cerebral white matter significantly changed during the cardiac cycle, and this change (delta-ADC) assisted in the diagnosis of idiopathic normal pressure hydrocephalus (INPH). While a cerebrospinal fluid tap test is one of the useful methods for the diagnosis of INPH. The aim of this study was to assess how much change in the delta-ADC of the brain in INPH before and after the tap test. Delta-ADC analysis makes it possible to noninvasively provide information of change in the intracranial condition after the tap test.