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Abstract #3231

The Effect of Spatial Resolution on Structural Connectome Analysis

Arnaud Guidon1, 2, Anastasyia Batrachenko, 23, Alexandru Vlad Avram4, Allen W. Song2

1Biomedical Engineering, Duke University, Durham, NC, United States; 2Brain Imaging and Analysis Center, Duke University, Durham, NC, United States; 3Medical Physics, Duke University, Durham, NC, United States; 4National Institute of Health, Bethesda, MD, United States

Structural connectivity studies permit a comprehensive investigation of white matter fiber networks in the human brain and as such hold promising potential for the advancement of our understanding of healthy and pathological cortical development. However, the truthful depiction of the structural connectome relies heavily on the quality and completeness of the diffusion tensor acquisition. In this work, we compare connectomes acquired respectively with voxel sizes of 3x3x3mm3, 2x2x2mm3 and 1x1x1mm3 and show that the derived connectivity metrics benefit greatly from increased spatial resolution.