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Abstract #3241

Cortical Layers One by One: Diffusion Properties at 160μm Resolution

Ana-Maria Oros-Peusquens1, Alard Roebroeck2, Daniel Brenner1, Klaus Moellenhoff1, 2, Avdo Celik1, Joerg Felder1, Andreas Matusch1, Ralf A.W. Galuske3, Hansju

1INM-4, Research Centre Juelich, Juelich, Germany; 2Dept. of Psychology, University of Maastricht, Netherlands; 3Dept. of Biology, TU Darmstadt, Germany; 4Dept. of Forensic Medicine, Faculty of Medicine, JWG-University, Frankfurt/M, Germany; 5Faculty of Medicine, JARA, RWTH Aachen University, Germany

A high-resolution diffusion study was performed on a piece of tissue containing the central sulcus (motor and sensory cortex). Clear intracortical contrast was observed, consisting regionally of two bands with strikingly different T2 and, to some extent, diffusion contrast from the surrounding grey matter. Their precise cyto- and myeloarchitectonic origin remains to be clarified by histology (in progress). The GM and WM of the fixed tissue were characterised by their ADC and FA values and we found very good correspondence to values obtained previously and with a different method for the visual cortex.