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Abstract #3252

Intravoxel Incoherent Motion (IVIM) in Healthy Skeletal Muscle Pre- And Post-Exercise

Eric E. Sigmund1, Steven Baete1, Gene Y. Cho1, Dabang Sui1, Thompson Ukpebor1, Kecheng Liu2, Jane Kwon1, Kellyanne McGorty1, Jenny Bencardino1

1Radiology, NYU Langone Medical Center, New York, NY, United States; 2Siemens Medical Systems

Skeletal muscle pathologies can have both microstructural and microvascular underpinnings to which diffusion-weighted imaging can be made sensitive through the intravoxel incoherent motion (IVIM) approach. We performed IVIM in healthy calf muscles at 3 T both before and after treadmill exertion, and evaluated the biomarkers of tissue diffusivity, perfusion fraction, and pseudodiffusivity in 7 different muscle compartments and three orthogonal directions. The largest and most significant changes occurred for perfusion fraction, which isotropically increased by ~50%. Results are discussed in the context of muscle physiology and the sensitivities of diffusion contrast.